diff --git a/src/humanize/lists.py b/src/humanize/lists.py
index 36e8ab73..fe4aef60 100644
--- a/src/humanize/lists.py
+++ b/src/humanize/lists.py
@@ -10,7 +10,7 @@
 __all__ = ["natural_list"]
 
 
-def natural_list(items: Iterable[Any]) -> str:
+def natural_list(items: Iterable[Any], oxford_comma: bool = False) -> str:
     """Natural list.
 
     Convert an iterable of items into a human-readable string with commas and 'and'.
@@ -18,6 +18,8 @@ def natural_list(items: Iterable[Any]) -> str:
     Examples:
         >>> natural_list(["one", "two", "three"])
         'one, two and three'
+        >>> natural_list(["one", "two", "three"], oxford_comma=True)
+        'one, two, and three'
         >>> natural_list(["one", "two"])
         'one and two'
         >>> natural_list(["one"])
@@ -25,6 +27,8 @@ def natural_list(items: Iterable[Any]) -> str:
 
     Args:
         items (Iterable): An iterable of items.
+        oxford_comma (bool): Include a comma before 'and' for three or more items.
+            Defaults to False.
 
     Returns:
         str: A string with commas and 'and' in the right places.
@@ -37,4 +41,5 @@ def natural_list(items: Iterable[Any]) -> str:
     elif len(item_list) == 2:
         return f"{item_list[0]} and {item_list[1]}"
     else:
-        return ", ".join(item_list[:-1]) + f" and {item_list[-1]}"
+        separator = ", and " if oxford_comma else " and "
+        return ", ".join(item_list[:-1]) + separator + item_list[-1]
diff --git a/tests/test_lists.py b/tests/test_lists.py
index 9b3c1b77..67c5fda2 100644
--- a/tests/test_lists.py
+++ b/tests/test_lists.py
@@ -29,3 +29,26 @@
 )
 def test_natural_list(test_args: Iterable[Any], expected: str) -> None:
     assert humanize.natural_list(*test_args) == expected
+
+
+@pytest.mark.parametrize("oxford_comma", [False, True])
+@pytest.mark.parametrize(
+    "items, without_comma, with_comma",
+    [
+        ([], "", ""),
+        (["one"], "one", "one"),
+        (["one", "two"], "one and two", "one and two"),
+        (["one", "two", "three"], "one, two and three", "one, two, and three"),
+        ([1, 2, 3, 4], "1, 2, 3 and 4", "1, 2, 3, and 4"),
+    ],
+)
+def test_natural_list_oxford_comma(
+    items: list[Any], without_comma: str, with_comma: str, oxford_comma: bool
+) -> None:
+    expected = with_comma if oxford_comma else without_comma
+    assert humanize.natural_list(items, oxford_comma=oxford_comma) == expected
+
+
+def test_natural_list_oxford_comma_generator() -> None:
+    items = (item for item in ["one", "two", "three"])
+    assert humanize.natural_list(items, oxford_comma=True) == "one, two, and three"