diff --git a/PCbuild/pyproject.props b/PCbuild/pyproject.props
index 53bfe5e3ea95cc..17d4773367047f 100644
--- a/PCbuild/pyproject.props
+++ b/PCbuild/pyproject.props
@@ -38,6 +38,8 @@
     <!-- See https://developercommunity.visualstudio.com/t/Regression-in-MSVC-1433-1434-ARM64-co/10224361 -->
     <MSVCHasBrokenARM64Clamping Condition="$(_VCToolsVersion) == '14.34' or $(_VCToolsVersion) == '14.35'">true</MSVCHasBrokenARM64Clamping>
     <MSVCHasBrokenARM64SignExtension Condition="$(_VCToolsVersion) == '14.37'">true</MSVCHasBrokenARM64SignExtension>
+    <!-- See gh-153668 and https://developercommunity.visualstudio.com/t/ARM64-compiler-uses-excessive-memory-on/11120089 -->
+    <MSVCHasBrokenARM64UniDbOpt Condition="$(_VCToolsVersion) == '14.50' or $(_VCToolsVersion) == '14.51'">true</MSVCHasBrokenARM64UniDbOpt>
   </PropertyGroup>
 
   <PropertyGroup>
diff --git a/PCbuild/pythoncore.vcxproj b/PCbuild/pythoncore.vcxproj
index 69d83764fbe94b..5099e44020ec50 100644
--- a/PCbuild/pythoncore.vcxproj
+++ b/PCbuild/pythoncore.vcxproj
@@ -555,7 +555,10 @@
     <ClCompile Include="..\Objects\tupleobject.c" />
     <ClCompile Include="..\Objects\typeobject.c" />
     <ClCompile Include="..\Objects\typevarobject.c" />
-    <ClCompile Include="..\Objects\unicodectype.c" />
+    <ClCompile Include="..\Objects\unicodectype.c">
+      <!-- gh-153668: Temporarily disabled due to a compiler bug -->
+      <Optimization Condition="$(Platform) == 'ARM64' and $(Configuration) == 'Release' and $(MSVCHasBrokenARM64UniDbOpt) == 'true'">Disabled</Optimization>
+    </ClCompile>
     <ClCompile Include="..\Objects\unicodeobject.c" />
     <ClCompile Include="..\Objects\unionobject.c" />
     <ClCompile Include="..\Objects\weakrefobject.c" />